Mechanical Proofreading: A General Mechanism to Enhance the Fidelity of Information Transfer Between Cells

@inproceedings{Brockman2019MechanicalPA,
  title={Mechanical Proofreading: A General Mechanism to Enhance the Fidelity of Information Transfer Between Cells},
  author={Joshua M. Brockman and Khalid Salaita},
  booktitle={Front. Phys.},
  year={2019}
}
The cells and receptors of the immune system are mechanically active. Single molecule force spectroscopy, traction force microscopy, and molecular tension probe measurements all point to the importance of piconewton (pN) molecular forces in immune function. For example, forces enhance the ability of a T-cell to discriminate between nearly identical antigens. The role of molecular forces at these critical immune recognition junctions is puzzling as mechanical forces generally facilitate bond… CONTINUE READING
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References

Publications referenced by this paper.
SHOWING 1-10 OF 85 REFERENCES

Force-dependent transition in the T-cell receptor β-subunit allosterically regulates peptide discrimination and pMHC bond lifetime.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2015
VIEW 6 EXCERPTS
HIGHLY INFLUENTIAL

Models for the specific adhesion of cells to cells

GI Bell
  • Science
  • 1978
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

DNA-based nanoparticle tension sensors reveal that T-cell receptors transmit defined pN forces to their antigens for enhanced fidelity.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2016
VIEW 8 EXCERPTS
HIGHLY INFLUENTIAL

Insights into the initiation of TCR signaling

  • Nature Immunology
  • 2014
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Direct observation of catch bonds involving cell-adhesion molecules

BT Marshall, LongM, +3 authors C. Zhu
  • Nature
  • 2003
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

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