Mechanical Loading Stimulates Expression of Collagen Cross-Linking Associated Enzymes in Periodontal Ligament.

@article{Kaku2016MechanicalLS,
  title={Mechanical Loading Stimulates Expression of Collagen Cross-Linking Associated Enzymes in Periodontal Ligament.},
  author={Masaru Kaku and Juan Marcelo Rosales Rocabado and Megumi Kitami and Takako Ida and Yosuke Akiba and M. Degawa Yamauchi and Katsumi Uoshima},
  journal={Journal of cellular physiology},
  year={2016},
  volume={231 4},
  pages={
          926-33
        }
}
Type I collagen, a major extracellular component of the periodontal ligament (PDL), is post-translationally modified by a series of specific enzymes. Among the collagen-modifying enzymes, lysyl oxidase (LOX) is essential to initiate collagen cross-linking and lysyl hydroxylases (LHs) to regulate the cross-linking pathways that are important for tissue specific mechanical properties. The purpose of this study was to investigate the effects of mechanical loading on the expression of collagen… CONTINUE READING
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