Mechanical Forces in Endothelial Cells during Firm Adhesion and Early Transmigration of Human Monocytes.

@article{Liu2010MechanicalFI,
  title={Mechanical Forces in Endothelial Cells during Firm Adhesion and Early Transmigration of Human Monocytes.},
  author={Zhijun Liu and Nathan John Sniadecki and Christopher S. Chen},
  journal={Cellular and molecular bioengineering},
  year={2010},
  volume={3 1},
  pages={50-59}
}
Transmigration of leukocytes across the endothelial barrier is a tightly controlled process involving multiple steps, including rolling adhesion, firm adhesion, and then penetration of leukocytes through the endothelial monolayer. While the key molecular signals have been described in great detail, we are only just beginning to unveil the mechanical forces involved in this process. Here, using a microfabricated system that reports traction forces generated by cells, we describe forces generated… CONTINUE READING

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