Mechanical Devices of the Spliceosome: Motors, Clocks, Springs, and Things
@article{Staley1998MechanicalDO, title={Mechanical Devices of the Spliceosome: Motors, Clocks, Springs, and Things}, author={Jonathan P. Staley and Christine Guthrie}, journal={Cell}, year={1998}, volume={92}, pages={315-326} }
1,145 Citations
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It is shown that nearly every major process in a cell is 10 RNA rearrangements as it removes an intron from an carried out by assemblies of 10 or more protein moleRNA transcript, and that protein assemmore elaborate and sophisticated than anything the authors stublies can be enormously complex.
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Drosophila MFAP1 Is Required for Pre-mRNA Processing and G2/M Progression*
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In vivo data show that cells with reduced levels of dMFAP1 or dPrp38 proliferate more slowly than normal cells and undergo apoptosis, suggesting that the observed G2/M arrest might be a general consequence of interfering with spliceosome function.
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Bicaudal D induces selective dynein‐mediated microtubule minus end‐directed transport
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The N–terminal portion of human Bicaudal D2 (BICD2) is capable of inducing microtubule minus end‐directed movement independently of the molecular context, which offers a new tool to exploit the relocalization of different cellular components by using appropriate targeting motifs.
Purification of Drosophila snRNPs and characterization of two populations of functional U1 particles.
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The purification of U1 snRNP particles from Drosophila nuclear extracts are reported and the characterization of their biochemical properties, polypeptide contents, and splicing activities reinforce the view that their activity and composition, with the exception of the atypical bifunctional U1-A/U2-B" SNF protein, are highly conserved in metazoans.
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