Mechanical Activation Of Piezo1 But Not Nav1.2 Channels By Ultrasound

  title={Mechanical Activation Of Piezo1 But Not Nav1.2 Channels By Ultrasound},
  author={Martin Loynaz Prieto and Kamyar Firouzi and Butrus T. Khuri-Yakub and Merritt Maduke},
Ultrasound can modulate the electrical activity of the brain and other excitable tissues but the mechanisms underlying this effect are not understood, either at the molecular level or in terms of the physical modality through which ultrasound exerts its effects. An obvious approach to address this question would be to measure ultrasounds effects on specific candidate ion channels using patch-clamp recording, but ultrasound at the most commonly used frequencies permanently damages the gigaohm… CONTINUE READING
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