Mecanismo de accion de miotoxinas aisladas de venenos de serpientes

@article{Gutirrez1984MecanismoDA,
  title={Mecanismo de accion de miotoxinas aisladas de venenos de serpientes},
  author={Jos{\'e} Mar{\'i}a Guti{\'e}rrez and Luis Cerdas},
  journal={Revista De Biologia Tropical},
  year={1984},
  volume={32},
  pages={213-222}
}
Biochemically and pharmacologically, myotoxins isolated from snake venoms can be placed in four main groups: myotoxic phospholipases A, low molecular weight basic toxins, cardiotoxins, and hemorrhagic myotoxins. The myotoxic phospholipases A notexin, taipoxin, crotoxin, and Bothrops asper myotoxin induce muscle necrosis by first affecting the integrity of the plasma membrane, thereby inducing a calcium influx that culminates in cell death. The small basic myotoxin crotamine acts on the voltage… 
Detection of proteins antigenically related to Bothrops asper myotoxin in crotaline snake venoms.
Mechanistic insights into functional characteristics of native crotamine
Toxicidade seletiva da crotamina do veneno de Crotalus durissus terrificus sobre as células indutoras de tumores.
TLDR
It is demonstrated that crotamine possesses in vitro and in vivo specific and selective cytotoxic activity against aggressive and fast growing types of tumor.
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TLDR
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TLDR
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TLDR
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