Mecanismo de accion de miotoxinas aisladas de venenos de serpientes

@article{Gutirrez1984MecanismoDA,
  title={Mecanismo de accion de miotoxinas aisladas de venenos de serpientes},
  author={Jos{\'e} Mar{\'i}a Guti{\'e}rrez and Luis Cerdas},
  journal={Revista De Biologia Tropical},
  year={1984},
  volume={32},
  pages={213-222}
}
Biochemically and pharmacologically, myotoxins isolated from snake venoms can be placed in four main groups: myotoxic phospholipases A, low molecular weight basic toxins, cardiotoxins, and hemorrhagic myotoxins. The myotoxic phospholipases A notexin, taipoxin, crotoxin, and Bothrops asper myotoxin induce muscle necrosis by first affecting the integrity of the plasma membrane, thereby inducing a calcium influx that culminates in cell death. The small basic myotoxin crotamine acts on the voltage… 
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The effect of myotoxins isolated from Bothrops snake venoms on multilamellar liposomes: relationship to phospholipase A2, anticoagulant and myotoxic activities.
Influence of phospholipasic inhibition on neuromuscular activity of Bothrops fonsecai snake venom
An overview of lysine-49 phospholipase A2 myotoxins from crotalid snake venoms and their structural determinants of myotoxic action.
Skeletal muscle necrosis induced by a phospholipase A2 isolated from the venom of the coral snake Micrurus nigrocinctus nigrocinctus.
Detection of proteins antigenically related to Bothrops asper myotoxin in crotaline snake venoms.
Efectos farmacologicos y enzimaticos de los venenos de serpientes de Antioquia y Choco (Colombia)
Mechanistic insights into functional characteristics of native crotamine
Snake venomics and antivenomics of Crotalus durissus subspecies from Brazil: assessment of geographic variation and its implication on snakebite management.
Biochemical and biological activities of the venom of the Chinese pitviper Zhaoermia mangshanensis, with the complete amino acid sequence and phylogenetic analysis of a novel Arg49 phospholipase A2 myotoxin.
Toxicidade seletiva da crotamina do veneno de Crotalus durissus terrificus sobre as células indutoras de tumores.
TLDR
It is demonstrated that crotamine possesses in vitro and in vivo specific and selective cytotoxic activity against aggressive and fast growing types of tumor.
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References

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TLDR
High serum creatine kinase activity of mice injected with the toxin substantiates the destructive action of viriditoxin on muscle and indicates the protein is also moderately lethal in addition to its tissue damaging effect.
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TLDR
The pathogenesis of myonecrosis induced by a purified component of rattlesnake (Crotalus viridis viridis) venom was studied at the light and electron microscopic levels, with the pure component altered skeletal muscle cells specifically, withThe sarcoplasmic reticulum being the primary site of action.
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TLDR
The experimental injection of three purified hemorrhagic toxins induced hemorrhage by the same mechanism as does the crude venom, ie, per rhexis, in addition, one of the toxins, hemorrhagic toxin beta, causes myonecrosis.
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TLDR
The circular dichroic spectrum indicates that the chemically modified, inactive myotoxin exhibits typical random-coil conformation.
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TLDR
Snake venoms and other toxic secretions contain a large number of pharmacologically highly active substances with a specific mode of action designed to affect vital processes, such as the function of nerves and muscles, the action of the heart, the circulation of the blood, and the permeability of membranes.
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TLDR
Mojave toxin showed antigenic similarities to crotoxin, the lethal neurotoxin in the venom of the South American rattlesnake, as determined by the ability of antiserum raised against crot toxin to neutralize Mojave toxin.
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