Mecamylamine-precipitated nicotine-withdrawal aversion in rats.

  title={Mecamylamine-precipitated nicotine-withdrawal aversion in rats.},
  author={Tsutomu Suzuki and Yuya Ise and Makoto Tsuda and Jun-ichi Maeda and Miwa Misawa},
  journal={European journal of pharmacology},
  volume={314 3},
The present study examined a rapid and convenient model for evaluating nicotine dependence using the conditioned place preference paradigm. Rats were chronically infused subcutaneously with 9 mg/kg per day nicotine using an osmotic minipump. After nicotine infusion for 7 days, the nicotinic receptor antagonist mecamylamine produced a place aversion in nicotine-dependent rats, but not in acute nicotine-treated rats or sham-operated rats. These results suggest that the mecamylamine-precipitated… CONTINUE READING

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