Mecamylamine modifies the pharmacokinetics and reinforcing effects of alcohol.

@article{Blomqvist2002MecamylamineMT,
  title={Mecamylamine modifies the pharmacokinetics and reinforcing effects of alcohol.},
  author={Ola Blomqvist and Carlos A. Hern{\'a}ndez-{\'A}vila and Jeffrey Van Kirk and Jed E. Rose and Henry R. Kranzler},
  journal={Alcoholism, clinical and experimental research},
  year={2002},
  volume={26 3},
  pages={
          326-31
        }
}
BACKGROUND Central nicotinic cholinergic receptors modify alcohol-induced mesolimbic dopamine activation, which seems to be important in the reinforcing properties of alcohol. Consistent with this model, acute administration to rats of the tertiary nicotinic receptor antagonist mecamylamine blocks both alcohol consumption and alcohol-induced dopamine release in the nucleus accumbens. This study was conducted to test the hypothesis that, during the ascending limb of the blood alcohol… 
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Conditional and non-conditional reward- related responses to alcohol - nicotinic mechanisms
TLDR
A novel mechanism by which alcohol-associated cues stimulate mesolimbic dopamine activity and promote drug-seeking behavior by activation of VTA α3β2* and/or α6* nAChRs is hypothesized, which may explain the enhanced sugar intake associated with smoking cessation and alcohol abstinence.
The Smoking Cessation Medication Varenicline Attenuates Alcohol and Nicotine Interactions in the Rat Mesolimbic Dopamine System
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The antismoking agent varenicline exhibits properties with respect to its interaction with ethanol and nicotine in the brain reward system that may be beneficial for treating patients with alcohol dependence with (and possibly also without) concomitant nicotine dependence.
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