Mecamylamine attenuates the subjective stimulant-like effects of alcohol in social drinkers.

@article{Chi2003MecamylamineAT,
  title={Mecamylamine attenuates the subjective stimulant-like effects of alcohol in social drinkers.},
  author={Henry Chi and Harriet de Wit},
  journal={Alcoholism, clinical and experimental research},
  year={2003},
  volume={27 5},
  pages={
          780-6
        }
}
  • Henry Chi, H. de Wit
  • Published 1 May 2003
  • Medicine
  • Alcoholism, clinical and experimental research
BACKGROUND Recent studies have implicated central nicotinic cholinergic receptor systems in the reinforcing properties of alcohol. In laboratory animals, mecamylamine, a central nicotinic receptor antagonist, reduces the consumption of and preference for alcohol. This study investigated the effect of mecamylamine on the subjective responses to alcohol in humans. It was hypothesized that mecamylamine (7.5 and 15 mg) would attenuate the stimulant-like subjective effects of alcohol (0.8 g/kg) and… 
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