Mecamylamine and ethanol preference in healthy volunteers.

@article{Young2005MecamylamineAE,
  title={Mecamylamine and ethanol preference in healthy volunteers.},
  author={Elizabeth Young and Stephen V. Mahler and Henry Chi and Harriet de Wit},
  journal={Alcoholism, clinical and experimental research},
  year={2005},
  volume={29 1},
  pages={
          58-65
        }
}
BACKGROUND Recent evidence suggests that some of the behavioral effects of alcohol may be mediated through actions on nicotinic acetylcholine receptors. Mecamylamine, a nicotinic acetylcholine receptor antagonist, reduces alcohol preference and consumption in alcohol-preferring rats, and in humans, mecamylamine dampens some of the subjective, or mood-altering, effects of alcohol. This experiment was designed to investigate the effects of mecamylamine on consumption of alcohol in healthy social… 
View on PubMed
doi.org
64 Citations
Highly Influential Citations
4
Background Citations
25
Methods Citations
5
Results Citations
7

64 Citations

Citation Type

Citation Type

Varenicline Reduces Alcohol Self-Administration in Heavy-Drinking Smokers
The influence of mecamylamine on ethanol and sucrose self-administration
Varenicline potentiates alcohol-induced negative subjective responses and offsets impaired eye movements.
TLDR
The data support the theory that VAR may reduce drinking by potentiating aversive effects of alcohol and offsets alcohol-induced eye movement impairment, and suggest that Var may decrease alcohol consumption by producing effects that oppose the rewarding efficacy of alcohol.
Differential effects of nicotine on alcohol consumption in men and women
TLDR
The findings extend existing data on sex differences in the effects of either nicotine or cigarette smoking on alcohol consumption, and support the idea that the pharmacological effects of nicotine may differ in men and women.
The Smoking Cessation Medication Varenicline Attenuates Alcohol and Nicotine Interactions in the Rat Mesolimbic Dopamine System
TLDR
The antismoking agent varenicline exhibits properties with respect to its interaction with ethanol and nicotine in the brain reward system that may be beneficial for treating patients with alcohol dependence with (and possibly also without) concomitant nicotine dependence.
Inhibitory influence of mecamylamine on the development and the expression of ethanol-induced locomotor sensitization in mice
Varenicline, an α4β2 nicotinic acetylcholine receptor partial agonist, selectively decreases ethanol consumption and seeking
TLDR
The selectivity of varenicline in decreasing ethanol consumption combined with its reported safety profile and mild side effects in humans suggest that varenICline may prove to be a treatment for alcohol dependence.
Inhibitory influence of mecamylamine on ethanol withdrawal-induced symptoms in C57BL/6J mice
TLDR
It is suggested that mecamylamine exhibited inhibitory effects on ethanol withdrawal signs which could be mediated through nAChR, thus supporting the contention that nA ChR is involved in ethanol dependence.
Nicotinic Cholinergic Mechanisms in Alcohol Abuse and Dependence
Interactions between mecamylamine and alcohol in Long–Evans rats: Flash-evoked potentials, body temperature, behavior, and blood alcohol concentration
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 40 REFERENCES
Mecamylamine attenuates the subjective stimulant-like effects of alcohol in social drinkers.
TLDR
Findings suggest that nicotinic cholinergic receptors are involved in mediating some of the stimulant-like effects of alcohol, particularly in men, even though women exhibited greater physiologic reactions to mecamylamine.
Mecamylamine modifies the pharmacokinetics and reinforcing effects of alcohol.
TLDR
Mecamylamine seems to modify both the pharmacokinetic profile of alcohol and the rewarding effects of alcohol in healthy volunteers.
Mecamylamine Blockade of Both Positive and Negative Effects of IV Nicotine in Human Volunteers
Voluntary ethanol intake in the rat: effects of nicotinic acetylcholine receptor blockade or subchronic nicotine treatment.
Involvement of nicotinic receptors in alcohol self-administration.
TLDR
The stimulation of alcohol intake induced by nicotine treatment and the suppression of alcohol consumption induced by mecamylamine provide evidence for the involvement of nicotinic receptors in alcohol consumption and/or self-administration.
Naltrexone effects on alcohol consumption in a clinical laboratory paradigm: temporal effects of drinking
TLDR
There may be a time-critical period between drinks necessary for alcoholics to benefit from its effects, consistent with clinical trial data that suggest a potential synergistic effect between relapse prevention therapies and opiate antagonist pharmacotherapy.
Pretreatment with transdermal nicotine enhances some of ethanol's acute effects in men.
Neurochemical and behavioral studies on ethanol and nicotine interactions
Role of different nicotinic acetylcholine receptors in mediating behavioral and neurochemical effects of ethanol in mice.
Naltrexone decreases craving and alcohol self-administration in alcohol-dependent subjects and activates the hypothalamo–pituitary–adrenocortical axis
TLDR
The hypothesis that naltrexone reduces desire to drink and the amount of alcohol consumed in alcohol-dependent subjects is confirmed, and this effect may be related in part to nALTrexone's ability to activate the hypothalamo–pituitary–adrenocortical axis.
...
1
2
3
4
...