Mecamylamine and ethanol preference in healthy volunteers.

@article{Young2005MecamylamineAE,
  title={Mecamylamine and ethanol preference in healthy volunteers.},
  author={Elizabeth Young and Stephen V. Mahler and Henry Chi and Harriet de Wit},
  journal={Alcoholism, clinical and experimental research},
  year={2005},
  volume={29 1},
  pages={
          58-65
        }
}
BACKGROUND Recent evidence suggests that some of the behavioral effects of alcohol may be mediated through actions on nicotinic acetylcholine receptors. Mecamylamine, a nicotinic acetylcholine receptor antagonist, reduces alcohol preference and consumption in alcohol-preferring rats, and in humans, mecamylamine dampens some of the subjective, or mood-altering, effects of alcohol. This experiment was designed to investigate the effects of mecamylamine on consumption of alcohol in healthy social… 
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References

SHOWING 1-10 OF 40 REFERENCES
Mecamylamine attenuates the subjective stimulant-like effects of alcohol in social drinkers.
TLDR
Findings suggest that nicotinic cholinergic receptors are involved in mediating some of the stimulant-like effects of alcohol, particularly in men, even though women exhibited greater physiologic reactions to mecamylamine.
Mecamylamine modifies the pharmacokinetics and reinforcing effects of alcohol.
TLDR
Mecamylamine seems to modify both the pharmacokinetic profile of alcohol and the rewarding effects of alcohol in healthy volunteers.
Involvement of nicotinic receptors in alcohol self-administration.
TLDR
The stimulation of alcohol intake induced by nicotine treatment and the suppression of alcohol consumption induced by mecamylamine provide evidence for the involvement of nicotinic receptors in alcohol consumption and/or self-administration.
Naltrexone effects on alcohol consumption in a clinical laboratory paradigm: temporal effects of drinking
TLDR
There may be a time-critical period between drinks necessary for alcoholics to benefit from its effects, consistent with clinical trial data that suggest a potential synergistic effect between relapse prevention therapies and opiate antagonist pharmacotherapy.
Neurochemical and behavioral studies on ethanol and nicotine interactions
Naltrexone decreases craving and alcohol self-administration in alcohol-dependent subjects and activates the hypothalamo–pituitary–adrenocortical axis
TLDR
The hypothesis that naltrexone reduces desire to drink and the amount of alcohol consumed in alcohol-dependent subjects is confirmed, and this effect may be related in part to nALTrexone's ability to activate the hypothalamo–pituitary–adrenocortical axis.
...
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