Mecamylamine acutely increases human intravenous nicotine self-administration

@article{Rose2003MecamylamineAI,
  title={Mecamylamine acutely increases human intravenous nicotine self-administration},
  author={Jerzy E. Rose and Fr{\'e}d{\'e}rique M. Behm and Eric C Westman and James E Bates},
  journal={Pharmacology Biochemistry and Behavior},
  year={2003},
  volume={76},
  pages={307-313}
}
Previous studies of human cigarette smoking have shown that administration of the nicotinic acetylcholine receptor antagonist mecamylamine produces acute increases in smoking behavior. In contrast, studies of intravenous nicotine self-administration in animals typically show an immediate decrease in self-administration behavior following mecamylamine administration. To investigate whether this discrepancy might be due in part to the mode of nicotine self-administration (intravenous vs… CONTINUE READING
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