Mecamylamine – a nicotinic acetylcholine receptor antagonist with potential for the treatment of neuropsychiatric disorders

@article{Bacher2009MecamylamineA,
  title={Mecamylamine – a nicotinic acetylcholine receptor antagonist with potential for the treatment of neuropsychiatric disorders},
  author={Ingrid Bacher and Becky S. Wu and Douglas Ronald Shytle and Tony P. George},
  journal={Expert Opinion on Pharmacotherapy},
  year={2009},
  volume={10},
  pages={2709 - 2721}
}
Mecamylamine (Inversine®), the first orally available antihypertensive agent launched in the 1950s, is rarely used today for hypertension because of its widespread ganglionic side effects at antihypertensive doses (25 – 90 mg/day). However, more recent clinical studies suggest that mecamylamine is effective at much lower doses for blocking the central and peripheral effects of nicotine. Pharmacologically, mecamylamine has been well characterized as a nonselective and noncompetitive antagonist… 

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TLDR
Low-dose mecamylamine therapy might reduce blood pressure variability and atherogenetic lipid profile in smokers and be an important research tool in the field of hypertension research, particularly in recalcitrant smokers with mild to moderate hypertension.

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TLDR
Preliminary evidence is presented suggesting that the potent, centrally acting nAChR antagonist, mecamylamine, which is devoid of monoamine reuptake inhibition, may reduce symptoms of depression and mood instability in patients with comorbid depression and bipolar disorder.

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TLDR
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TLDR
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