Meat-related mutagen exposure, xenobiotic metabolizing gene polymorphisms and the risk of advanced colorectal adenoma and cancer.

@article{Gilsing2012MeatrelatedME,
  title={Meat-related mutagen exposure, xenobiotic metabolizing gene polymorphisms and the risk of advanced colorectal adenoma and cancer.},
  author={Anne M. J. Gilsing and Sonja I. Berndt and Elizabeth H. Ruder and Barry I. Graubard and Leah M. Ferrucci and Laura Burdett and Joel L. Weissfeld and Amanda J. Cross and Rashmi Sinha},
  journal={Carcinogenesis},
  year={2012},
  volume={33 7},
  pages={1332-9}
}
Meat mutagens, including heterocyclic amines (HCAs), polycyclic aromatic hydrocarbons (PAHs) and N-nitroso compounds (NOCs), may be involved in colorectal carcinogenesis depending on their activation or detoxification by phase I and II xenobiotic metabolizing enzymes (XME). Using unconditional logistic regression to estimate odds ratios (OR) and 95% confidence intervals (CI), we examined the intake of five meat mutagens and >300 single nucleotide polymorphisms (SNPs) in 18 XME genes in relation… CONTINUE READING
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