Meat intake and bladder cancer in a prospective study: a role for heterocyclic aromatic amines?

  title={Meat intake and bladder cancer in a prospective study: a role for heterocyclic aromatic amines?},
  author={Blanca Lumbreras and Seymour J. Garte and Kim Overvad and Anne Tjonneland and Francoise Clavel-Chapelon and Jakob Linseisen and H. B{\"o}ing and Antonia Trichopoulou and Domenico Palli and Marco Peluso and Vittorio Krogh and Rosario Tumino and Salvatore Panico and Hendrik Bas Bueno-de-Mesquita and P. H. Peeters and Eiliv Lund and C. Mart{\'i}nez and Miren Dorronsoro and Aurelio Barricarte and M. -D. Chirlaque and Jos{\'e} Ram{\'o}n Quir{\'o}s and G{\"o}ran Berglund and Goran Hallmans and N. E. Day and Timothy J Key and Rodolfo Saracci and Rudolf Kaaks and Christian Malaveille and Pietro Ferrari and Paolo Boffetta and Teresa Norat and Eilo Riboli and Carlos A. Gonz{\'a}lez and Paolo Vineis},
  journal={Cancer Causes & Control},
The suspect carcinogens, heterocyclic amines (HAAs), found in well-done meat require host-mediated metabolic activation before inducing DNA mutations. The role of SULT1A1 and of NAT2 on the activation of HAAs suggests that NAT2 rapid acetylator genotype and SULT1A1 allele variants can have an effect on HAA carcinogenicity. Data were collected as part of a case–control study nested within the EPIC cohort, the Gen Air investigation. EPIC is a prospective study designed to investigate the… CONTINUE READING


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