Measuring the effects of supratherapeutic doses of levofloxacin on healthy volunteers using four methods of QT correction and periodic and continuous ECG recordings.

@article{Noel2004MeasuringTE,
  title={Measuring the effects of supratherapeutic doses of levofloxacin on healthy volunteers using four methods of QT correction and periodic and continuous ECG recordings.},
  author={Gary J. Noel and Daniel B. Goodman and Shuchean Chien and Bhavna Solanki and Mukund Padmanabhan and Jaya Sudha Natarajan},
  journal={Journal of clinical pharmacology},
  year={2004},
  volume={44 5},
  pages={464-73}
}
A clinical trial was conducted in healthy volunteers using both periodic and continuous ECG recordings to assess the effect of increasing doses of levofloxacin on the QT and QTc interval. Periodic and continuous ECGs were recorded before and after subjects were dosed with placebo and increasing doses of levofloxacin (500 mg, 1000 mg, 1500 mg) that included doses twice the maximum recommended dose of 750 mg in a double-blind, randomized, four-period, four-sequence crossover trial. Mean heart… CONTINUE READING

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