Measuring the activity of active efflux in gram-negative bacteria.

  title={Measuring the activity of active efflux in gram-negative bacteria.},
  author={Mark Alexander Webber and Nick G. Coldham},
  journal={Methods in molecular biology},
Resistance to clinically useful therapeutic antibiotics is an ever-increasing phenomenon seen in a range of bacterial species including those pathogenic to man. There are diverse mechanisms which contribute to inherent and acquired resistance to antibiotics. Gram-negative bacteria are commonly intrinsically more resistant to many drugs as a result of their cell structure and the activity of multidrug efflux pumps. Measurement of the accumulation of antibiotics and the contribution of active… CONTINUE READING

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