Measuring signaling by the unfolded protein response.

@article{Cox2011MeasuringSB,
  title={Measuring signaling by the unfolded protein response.},
  author={David J. Cox and Natalie Strudwick and A. M. Aswan Ali and Adrienne W Paton and James C Paton and Martin Schr{\"o}der},
  journal={Methods in enzymology},
  year={2011},
  volume={491},
  pages={261-92}
}
The unfolded protein response (UPR) is activated by accumulation of unfolded proteins in the endoplasmic reticulum (ER). The unfolded protein response is associated with many diseases, including cancer, metabolic diseases such as type II diabetes and fatty liver diseases, and neurodegenerative diseases, for example, Alzheimer's disease. The UPR is also activated by numerous toxic chemicals and modulates drug action. Therefore, the UPR becomes increasingly important in toxicological and… CONTINUE READING