Measuring protein synthesis by mass isotopomer distribution analysis (MIDA).

@article{Papageorgopoulos1999MeasuringPS,
  title={Measuring protein synthesis by mass isotopomer distribution analysis (MIDA).},
  author={Chris A. Papageorgopoulos and Kenny Caldwell and Cedric Howard Lane Shackleton and H Schweingrubber and Marc K. Hellerstein},
  journal={Analytical biochemistry},
  year={1999},
  volume={267 1},
  pages={
          1-16
        }
}
The measurement of protein kinetics by isotopic techniques has been hindered by the long-standing difficulty of accurately measuring the isotope content of the biosynthetic precursor pool (aminoacyl-tRNA in tissues). Mass isotopomer distribution analysis (MIDA) is a stable isotope-mass spectrometric (MS) technique for measuring biosynthetic precursor enrichments from measurements on a polymeric product, based on combinatorial probabilities of labeled and unlabeled monomeric subunits. Proteins… CONTINUE READING
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