Measuring multiple neurochemicals and related metabolites in blood and brain of the rhesus monkey by using dual microdialysis sampling and capillary hydrophilic interaction chromatography-mass spectrometry.

@article{Li2012MeasuringMN,
  title={Measuring multiple neurochemicals and related metabolites in blood and brain of the rhesus monkey by using dual microdialysis sampling and capillary hydrophilic interaction chromatography-mass spectrometry.},
  author={Juan Li and Veronika von Pf{\"o}stl and Daniel Zaldivar and Xiaozhe Zhang and Nikos K. Logothetis and Alexander Rauch},
  journal={Analytical and bioanalytical chemistry},
  year={2012},
  volume={402 8},
  pages={2545-54}
}
In vivo measurement of multiple functionally related neurochemicals and metabolites (NMs) is highly interesting but remains challenging in the field of basic neuroscience and clinical research. We present here an analytical method for determining five functionally and metabolically related polar substances, including acetylcholine (quaternary ammonium), lactate and pyruvate (organic acids), as well as glutamine and glutamate (amino acids). These NMs are acquired from samples of the brain and… CONTINUE READING
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