Measuring lymphocyte proliferation, survival and differentiation using CFSE time-series data

@article{Hawkins2007MeasuringLP,
  title={Measuring lymphocyte proliferation, survival and differentiation using CFSE time-series data},
  author={E. Hawkins and Mirja Hommel and M. Turner and F. Battye and J. Markham and P. Hodgkin},
  journal={Nature Protocols},
  year={2007},
  volume={2},
  pages={2057-2067}
}
Cellular proliferation is an essential feature of the adaptive immune response. The introduction of the division tracking dye carboxyfluorescein diacetate succinimidyl ester (CFSE) has made it possible to monitor the number of cell divisions during proliferation and to examine the relationship between proliferation and differentiation. Although qualitative examination of CFSE data may be useful, substantially more information about division and death rates can be extracted from quantitative… Expand
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  • 138
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  • 175
  • Highly Influenced
  • PDF
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  • 17
  • Highly Influenced
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References

SHOWING 1-10 OF 19 REFERENCES
Estimating Lymphocyte Division and Death Rates from CFSE Data
  • 116
  • PDF
Quantifying cell turnover using CFSE data.
  • 87
  • PDF
A model of immune regulation as a consequence of randomized lymphocyte division and death times
  • 156
  • PDF
Cell division regulates the T cell cytokine repertoire, revealing a mechanism underlying immune class regulation.
  • A. Gett, P. Hodgkin
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 1998
  • 398
  • PDF
Determination of lymphocyte division by flow cytometry.
  • 1,940
The rescaling method for quantifying the turnover of cell populations.
  • 54
  • PDF
Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays.
  • T. Mosmann
  • Biology, Medicine
  • Journal of immunological methods
  • 1983
  • 44,213
  • PDF
...
1
2
...