Measuring intratumor heterogeneity by network entropy using RNA-seq data

@article{Park2016MeasuringIH,
  title={Measuring intratumor heterogeneity by network entropy using RNA-seq data},
  author={Youngjune Park and Sangsoo Lim and Jin-Wu Nam and Sun Kim},
  journal={Scientific Reports},
  year={2016},
  volume={6}
}
Intratumor heterogeneity (ITH) is observed at different stages of tumor progression, metastasis and reouccurence, which can be important for clinical applications. We used RNA-sequencing data from tumor samples, and measured the level of ITH in terms of biological network states. To model complex relationships among genes, we used a protein interaction network to consider gene-gene dependency. ITH was measured by using an entropy-based distance metric between two networks, nJSD, with Jensen… 
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