Measuring intracellular calcium fluxes in high throughput mode.

  title={Measuring intracellular calcium fluxes in high throughput mode.},
  author={Chris Chambers and Fiona Smith and C. S. Williams and Sandra Marcos and Zhen Han Liu and Paul G Hayter and Giuseppe Ciaramella and Wilma W Keighley and Phil Gribbon and Andreas Sewing},
  journal={Combinatorial chemistry & high throughput screening},
  volume={6 4},
The measurement of intracellular calcium fluxes in real time is widely applied within the pharmaceutical industry to measure the activation of G-protein coupled receptors (GPCRhyp;s), either for pharmacological characterisation or to screen for new surrogate ligands. Initially restricted to G(q) coupled GPCRs, the introduction of promiscuous and chimeric G-proteins has further widened the application of these assays. The development of new calcium sensitive dyes and assays has provided… CONTINUE READING

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