Measuring impulsivity in mice using a novel operant delayed reinforcement task: effects of behavioural manipulations and d-amphetamine

@article{Isles2003MeasuringII,
  title={Measuring impulsivity in mice using a novel operant delayed reinforcement task: effects of behavioural manipulations and d-amphetamine},
  author={Anthony R Isles and Trevor Humby and Lawrence S. Wilkinson},
  journal={Psychopharmacology},
  year={2003},
  volume={170},
  pages={376-382}
}
The increasing use of genetically modified mice to probe genetic contributions to normal and abnormal behaviours requires the development of sensitive and selective behavioural tasks. To develop a discrete trial assay of impulsivity (delayed reinforcement) that is tractable in mice utilising a mouse operant nine-hole box apparatus and to specify the task with respect to behavioural and pharmacological manipulations. Mice were trained to respond with a nose-poke to one of two visual stimuli; one… CONTINUE READING