Measuring human complement activation by HLA antibodies.

  title={Measuring human complement activation by HLA antibodies.},
  author={Jota Watanabe and Juan C. Scornik},
  journal={Archives of pathology & laboratory medicine},
  volume={130 3},
CONTEXT The clinical significance of HLA antibodies in transplantation depends on their ability to activate complement, which is measured by the standard complement-dependent cytotoxicity test. Recent reports indicate that C3b measurement on target cells may be a better indicator of human complement activation than standard cytotoxicity. OBJECTIVE To determine the characteristics of the test, the role of other complement components, and the potential influence of the patient's own complement… CONTINUE READING