Measuring herpes simplex virus thymidine kinase reporter gene expression in vitro


The herpes simplex 1 virus thymidine kinase (HSV1-tk) positron emission tomography (PET) reporter gene (PRG) or its mutant HSV1-sr39tk are used to investigate intracellular molecular events in cultured cells and for imaging intracellular molecular events and cell trafficking in living subjects. Two in vitro methods are available to assay gene expression of… (More)
DOI: 10.1038/nprot.2006.334


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