Measuring departures from Hardy–Weinberg: a Markov chain Monte Carlo method for estimating the inbreeding coefficient

@article{Ayres1998MeasuringDF,
  title={Measuring departures from Hardy–Weinberg: a Markov chain Monte Carlo method for estimating the inbreeding coefficient},
  author={Karen L. Ayres and David J. Balding},
  journal={Heredity},
  year={1998},
  volume={80},
  pages={769-777}
}
Many well-established statistical methods in genetics were developed in a climate of severe constraints on computational power. Recent advances in simulation methodology now bring modern, flexible statistical methods within the reach of scientists having access to a desktop workstation. We illustrate the potential advantages now available by considering the problem of assessing departures from Hardy–Weinberg (HW) equilibrium. Several hypothesis tests of HW have been established, as well as a… CONTINUE READING
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