Measuring cortisol in serum, urine and saliva – are our assays good enough?

@article{ElFarhan2017MeasuringCI,
  title={Measuring cortisol in serum, urine and saliva – are our assays good enough?},
  author={Nadia El-Farhan and Dafydd Aled Rees and Carol Evans},
  journal={Annals of Clinical Biochemistry},
  year={2017},
  volume={54},
  pages={308 - 322}
}
Cortisol is a steroid hormone produced in response to stress. It is essential for maintaining health and wellbeing and leads to significant morbidity when deficient or present in excess. It is lipophilic and is transported bound to cortisol-binding globulin (CBG) and albumin; a small fraction (∼10%) of total serum cortisol is unbound and biologically active. Serum cortisol assays measure total cortisol and their results can be misleading in patients with altered serum protein concentrations… Expand

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