Measuring cell adhesion forces with the atomic force microscope at the molecular level.

@article{Benoit2002MeasuringCA,
  title={Measuring cell adhesion forces with the atomic force microscope at the molecular level.},
  author={Martin Benoit and Hermann Eduard Gaub},
  journal={Cells, tissues, organs},
  year={2002},
  volume={172 3},
  pages={174-89}
}
In the past 25 years many techniques have been developed to characterize cell adhesion and to quantify adhesion forces. Atomic force microscopy (AFM) has been used to measure forces in the pico-newton range, an experimental technique known as force spectroscopy. We modified such an AFM to measure adhesion forces between live cells or between cells and surfaces. This strategy required functionalizing the surface of the sensors for immobilizing the cell. We used Dictyostelium discoideum cells… CONTINUE READING

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