Measuring brain atrophy with a generalized formulation of the boundary shift integral☆

Abstract

Brain atrophy measured using structural magnetic resonance imaging (MRI) has been widely used as an imaging biomarker for disease diagnosis and tracking of pathologic progression in neurodegenerative diseases. In this work, we present a generalized and extended formulation of the boundary shift integral (gBSI) using probabilistic segmentations to estimate… (More)
DOI: 10.1016/j.neurobiolaging.2014.04.035

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