Measuring bidirectional mutation.

  title={Measuring bidirectional mutation.},
  author={Carrie Jolly and Adam J. L. Cook and James M. Raftery and Michael Peyton Jones},
  journal={Journal of theoretical biology},
  volume={246 2},
The estimation of mutation rates is usually based on a model in which mutations are rare independent Poisson events. Back-mutation of mutants, an even rarer event, is ignored. In the hypermutating B cells of the immune system, mutation between phenotypes exhibiting, vs. not exhibiting, surface immunoglobulin is common in both directions. We develop three strategies for the estimation of mutation rates under circumstances such as these, where mutation rates in both directions are estimated… CONTINUE READING

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