Measuring behavior in mice with chronic stress depression paradigm.

@article{Strekalova2010MeasuringBI,
  title={Measuring behavior in mice with chronic stress depression paradigm.},
  author={Tatyana Strekalova and Harry W. M. Steinbusch},
  journal={Progress in neuro-psychopharmacology & biological psychiatry},
  year={2010},
  volume={34 2},
  pages={348-61}
}
Many studies with chronic stress, a common depression paradigm, lead to inconsistent behavioral results. We are introducing a new model of stress-induced anhedonia, which provides more reproducible induction and behavioral measuring of depressive-like phenotype in mice. First, a 4-week stress procedure induces anhedonia, defined by decreased sucrose preference, in the majority of but not all C57BL/6 mice. The remaining 30-50% non-anhedonic animals are used as an internal control for stress… CONTINUE READING
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