Measuring aging rates of mice subjected to caloric restriction and genetic disruption of growth hormone signaling

@inproceedings{Koopman2016MeasuringAR,
  title={Measuring aging rates of mice subjected to caloric restriction and genetic disruption of growth hormone signaling},
  author={Jacob J. E. Koopman and Diana van Heemst and David van Bodegom and Michael S. Bonkowski and Liou Y Sun and Andrzej Bartke},
  booktitle={Aging},
  year={2016}
}
  • Jacob J. E. Koopman, Diana van Heemst, +3 authors Andrzej Bartke
  • Published in Aging 2016
  • Biology, Medicine
  • Caloric restriction and genetic disruption of growth hormone signaling have been shown to counteract aging in mice. The effects of these interventions on aging are examined through age-dependent survival or through the increase in age-dependent mortality rates on a logarithmic scale fitted to the Gompertz model. However, these methods have limitations that impede a fully comprehensive disclosure of these effects. Here we examine the effects of these interventions on murine aging through the… CONTINUE READING

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