Measuring Intra-Cellular and Intra-Mitochondrial Zinc Concentrations Following Hypoxia/Hypoglycemia with an Expressible Ratiometric Fluorescence Biosensor

@inproceedings{McCranor2009MeasuringIA,
  title={Measuring Intra-Cellular and Intra-Mitochondrial Zinc Concentrations Following Hypoxia/Hypoglycemia with an Expressible Ratiometric Fluorescence Biosensor},
  author={Bryan J. McCranor and Linda L. Bambrick and Rebecca A. Bozym and Richard B. Thompson},
  year={2009}
}
Zinc is a “trace” metal necessary for proper cellular function. Studies have shown that the intra- and extra-cellular concentrations of labile zinc increase dramatically in models of cerebral ischemia (1) (2). Substantial evidence indicates that mitochondrial dysfunction plays a significant role in neuronal death following ischemia. Both mitochondrial dysfunction and increased intracellular zinc concentrations have been associated with increased reactive oxygen species (ROS) production and… CONTINUE READING