Measures of striatal insulin resistance in a 6-hydroxydopamine model of Parkinson's disease.

@article{Morris2008MeasuresOS,
  title={Measures of striatal insulin resistance in a 6-hydroxydopamine model of Parkinson's disease.},
  author={Jill K. Morris and Haopeng Zhang and Anisha A. Gupte and Gregory L. Bomhoff and John A. Stanford and Paige C Geiger},
  journal={Brain research},
  year={2008},
  volume={1240},
  pages={185-95}
}
Clinical evidence has shown a correlation between Parkinson's disease (PD) and Type 2 Diabetes (T2D), as abnormal glucose tolerance has been reported in >50% of PD patients. The development of insulin resistance and the degeneration of nigrostriatal dopamine (DA) neurons are both mediated by oxidative mechanisms, and oxidative stress is likely a mechanistic link between these pathologies. Although glucose uptake in neuronal tissues is primarily non-insulin dependent, proteins involved in… CONTINUE READING