Measures of gene expression in sputum cells can identify TH2-high and TH2-low subtypes of asthma.

@article{Peters2014MeasuresOG,
  title={Measures of gene expression in sputum cells can identify TH2-high and TH2-low subtypes of asthma.},
  author={Michael C Peters and Zesemayat K Mekonnen and Shaopeng Yuan and Nirav R Bhakta and Prescott G. Woodruff and John V Fahy},
  journal={The Journal of allergy and clinical immunology},
  year={2014},
  volume={133 2},
  pages={388-94}
}
BACKGROUND The 3-gene signature of periostin, chloride channel accessory 1 (CLCA1), and Serpin β2 (SERPINB2) in airway epithelial brushings is used to classify asthma into TH2-high and TH2-low endotypes. Little is known about the utility of gene profiling in sputum as a molecular phenotyping method. OBJECTIVE We sought to determine whether gene profiling in sputum cells can identify T(H)2-high and T(H)2-low subtypes of asthma. METHODS In induced sputum cell pellets from 37 asthmatic… CONTINUE READING