Measurements of mitochondrial pH in cultured cortical neurons clarify contribution of mitochondrial pore to the mechanism of glutamate-induced delayed Ca2+ deregulation.

@article{Bolshakov2008MeasurementsOM,
  title={Measurements of mitochondrial pH in cultured cortical neurons clarify contribution of mitochondrial pore to the mechanism of glutamate-induced delayed Ca2+ deregulation.},
  author={Alexey P. Bolshakov and M. M. Mikhaĭlova and Gy{\"o}rgy Szabadkai and Vsevolod G. Pinelis and Nickolay Brustovetsky and Rosario Rizzuto and Boris I. Khodorov},
  journal={Cell calcium},
  year={2008},
  volume={43 6},
  pages={
          602-14
        }
}
  • Alexey P. Bolshakov, M. M. Mikhaĭlova, +4 authors Boris I. Khodorov
  • Published in Cell calcium 2008
  • Biology, Medicine
  • To clarify the role of the mitochondrial permeability transition pore (MPT) in the mechanism of the glutamate-induced delayed calcium deregulation (DCD) and mitochondrial depolarization (MD), we studied changes in cytosolic (pH(c)) and mitochondrial pH (pH(m)) induced by glutamate in cultured cortical neurons expressing pH-sensitive fluorescent proteins. We found that DCD and MD were associated with a prominent pH(m) decrease which presumably resulted from MPT opening. This pH(m) decrease… CONTINUE READING

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