Measurements of membrane patch capacitance using a software-based lock-in system

  title={Measurements of membrane patch capacitance using a software-based lock-in system},
  author={Andreas Neef and Christian Heinemann and Tobias Moser},
  journal={Pfl{\"u}gers Archiv - European Journal of Physiology},
On-cell patch-clamp capacitance measurements can resolve the fusion of individual vesicles to a membrane patch and the accompanying dilation of the fusion pore. So far, these measurements have used a patch-clamp amplifier in combination with a hardware lock-in amplifier. Usually, solely the capacitance and conductance outputs of hardware lock-in amplifiers were recorded, which needed to be filtered rather heavily to suppress spectral components at the stimulus frequency. Therefore, the temporal… CONTINUE READING

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