Measurements of 45Ca2+ uptake and contractile responses after activation of postsynaptic alpha 1-adrenoceptors in the isolated canine saphenous vein: effects of calcium entry blockade.

@article{Jim1985MeasurementsO4,
  title={Measurements of 45Ca2+ uptake and contractile responses after activation of postsynaptic alpha 1-adrenoceptors in the isolated canine saphenous vein: effects of calcium entry blockade.},
  author={K. J. Jim and R M De Marinis and William D. Matthews},
  journal={European journal of pharmacology},
  year={1985},
  volume={107 2},
  pages={
          199-208
        }
}
The increase in 45Ca2+ content produced by the EC100 concentrations of a series of alpha 1-agonists in the canine saphenous vein (CSV) was determined in the presence of 10(-7) M rauwolscine and found to be correlated (r = 0.92) with the intrinsic activities of the alpha 1-agonists in CSV. The degree of inhibition of 45Ca2+ uptake by nifedipine (1 microM) was inversely correlated (r = -0.97) with the intrinsic activities of the alpha 1-agonists and also inversely correlated (r = -0.95) with the… CONTINUE READING
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