Corpus ID: 99634952

Measurementof True SalicylateConcentrationsin Serum from Patientswith

@inproceedings{Kang1983MeasurementofTS,
  title={Measurementof True SalicylateConcentrationsin Serum from Patientswith},
  author={E. Kang and T. A. Todd and M. T. Capaci and K. Schwenzer and J. Jabbour},
  year={1983}
}
1 Citations
Effect of Salicylic Acid on Mitochondrial-Peroxisomal Fatty Acid Catabolism
TLDR
Salicylic acid may potentiate the accumulation of fatty acids in plasma in Reye's syndrome patients by selective inhibition of mitochondrial oxidation of medium-chain (octanoic acid) and long- Chain fatty acids by salicylic Acid. Expand

References

SHOWING 1-10 OF 12 REFERENCES
SERUM SALICYLATE CONCENTRATIONS IN REYE'S DISEASE A Study of 130 Biopsy-proven Cases
TLDR
Serum salicylates are mitochondrial toxins and mitochondria are known to be significantly injured in Reye's disease; therefore, it seems wise to avoid the use of aspirin in children during outbreaks of Reye’s disease. Expand
Effects of aspirin and acetaminophen on the liver.
TLDR
The conditions of patients receiving long-term full doses of either aspirin or acetaminophen should be intermittently monitored for hepatic injury. Expand
Salicylates and Reye’s syndrome
Location of the medium chain fatty acid site on human serum albumin. Residues involved and relationship to the indole site.
TLDR
Human serum albumin (HSA) is found to contain one primary binding site for medium chain fatty acids which is competitive with the binding of N-acetyl-L-tryptophan, and the secondary binding sites formedium chain fatty acid are found to be the same general region as the primarybinding site. Expand
Reye's syndrome and salicylate use.
TLDR
It is postulated that salicylate, operating in a dose-dependent manner, possibly potentiated by fever, represents a primary causative agent of Reye's syndrome. Expand
Pharmacokinetics of salicylate in man.
  • G. Levy
  • Chemistry, Medicine
  • Drug metabolism reviews
  • 1979
Fatty acid binding to plasma albumin.
TLDR
A review of the available information about fatty acid binding to plasma albumin is presented, and stepwise association constants for binding to human albumin of fatty acids containing 6-18 carbon atoms indicate that each mole of fatty acid binds with a different affinity. Expand
Structural studies and organic ligand-binding properties of bovine plasma albumin.
TLDR
Binding studies showed that the tryptic fragment and defatted albumin both had one primary site for octanoate and l-tryptophan, thus suggesting that all three ligands bind at the same site. Expand
Structural changes in human serum albumin induced by ingestion of acetylsalicylic acid.
TLDR
Investigations were done to determine whether this phenomenon occurs in vivo and to delineate the site(s) of acetylation on the albumin molecule to establish a transacetylation reaction between aspirin and human albumin. Expand
Advanced organic chemistry
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