Measurement of tumour reactive antibody and antibody conjugate by competition, quantitated by flow cytofluorimetry.

Abstract

Binding of unlabelled monoclonal antibody preparations has been assessed by competition at saturation with fluorochrome labelled homologous antibody for binding to antigen bearing target cells. The extent of competition was measured by quantitative flow cytofluorimetry, and simple mathematical procedures have been developed to allow the interpretation of… (More)

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