Measurement of tumor interstitial volume fraction: method and implication for drug delivery.

@article{Kim2004MeasurementOT,
  title={Measurement of tumor interstitial volume fraction: method and implication for drug delivery.},
  author={Youngmi Kim and Mark D Savellano and Dagmar H{\"o}gemann Savellano and Ralph Weissleder and Alexei L. Bogdanov},
  journal={Magnetic resonance in medicine},
  year={2004},
  volume={52 3},
  pages={485-94}
}
It is important to evaluate the tumor interstitial volume fraction that is accessible for drug accumulation during the distribution phase in order to determine the potential efficacy of cancer chemotherapy. In this study, we performed simulations of magnetic resonance imaging (MRI) signal intensity using a two-compartment tissue model for quantitative analyses of absolute interstitial volume measurements while we experimentally characterized a mouse tumor model with a dual MR contrast-agent… CONTINUE READING

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