Measurement of transepidermal water loss (TEWL) in cats with experimental skin barrier dysfunction using a closed chamber system.

@article{Momota2016MeasurementOT,
  title={Measurement of transepidermal water loss (TEWL) in cats with experimental skin barrier dysfunction using a closed chamber system.},
  author={Yutaka Momota and Kenichiro Shimada and Azusa Gin and Takako Matsubara and Daigo Azakami and Katsumi Ishioka and Yuka Nakamura and Toshinori Sako},
  journal={Veterinary dermatology},
  year={2016},
  volume={27 5},
  pages={
          428-e110
        }
}
BACKGROUND A closed chamber evaporimeter is suitable for measuring transepidermal water loss (TEWL) in cats because of the compact device size, tolerance to sudden movement and short measuring time. TEWL is a representative parameter for skin barrier dysfunction, which is one of the clinical signs of atopic dermatitis in humans and dogs. Measurement of feline TEWL has been reported, but applicability of this parameter has not been validated. HYPOTHESIS/OBJECTIVES The aims of this study were… 
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TLDR
There is limited evidence of any useful correlation between clinical scoring systems and measurements of hydration, but the pinna may be a suitable region for the assessment of skin barrier function in normal and allergic cats.
Skin Barrier Dysfunction in Contact Dermatitis and Atopic Dermatitis-Treatment Implications
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New findings and treatment options for skin diseases with barrier dysfunction regarding their efficacy, safety profile and mechanism of action are investigated, emphasizing on contact dermatitis, hand eczema and atopic dermatitis.
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Insight is provided on the European Medicines Agency (EMA) guidelines for permeation studies and the parameters affected when using Franz diffusion cells in the permeation study.

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