Measurement of thiopurine S-methyltransferase activity in human blood samples based on high-performance liquid chromatography: reference values in erythrocytes from children.

@article{KeizerGarritsen2003MeasurementOT,
  title={Measurement of thiopurine S-methyltransferase activity in human blood samples based on high-performance liquid chromatography: reference values in erythrocytes from children.},
  author={Jenneke J Keizer-Garritsen and Connie Brouwer and Lambert H. J. Lambooy and Patricia G J H ter Riet and Jos P. M. B{\"o}kkerink and Frans J. M. Trijbels and Ronney A de Abreu},
  journal={Annals of clinical biochemistry},
  year={2003},
  volume={40 Pt 1},
  pages={86-93}
}
BACKGROUND Monitoring 6-thiopurine S-methyltransferase (TPMT; EC 2.1.1.67) activity is especially important when patients are treated with 6-thiopurine drugs, since severe bone marrow toxicity may be induced if patients have deficient TPMT activity. METHODS We have developed a method based on high-performance liquid chromatography (HPLC) for the… CONTINUE READING