Measurement of the 4,834-bp mitochondrial DNA deletion level in aging rat liver and brain subjected or not to caloric restriction diet.

@article{Cassano2004MeasurementOT,
  title={Measurement of the 4,834-bp mitochondrial DNA deletion level in aging rat liver and brain subjected or not to caloric restriction diet.},
  author={Pierluigi Cassano and Angela Maria Serena Lezza and Christiaan Leeuwenburgh and Palmiro Cantatore and Maria Nicola Gadaleta},
  journal={Annals of the New York Academy of Sciences},
  year={2004},
  volume={1019},
  pages={269-73}
}
Several studies have demonstrated an age-related accumulation of the amount of a specific 4834-bp mitochondrial DNA (mtDNA) deletion in different tissues of rat (liver, brain, and skeletal muscle). We investigated the influence of a caloric restriction diet (CR) on a selected age-associated marker of mtDNA damage, as the 4834-bp deletion, using quantitative… CONTINUE READING