Measurement of serum hepcidin-25 levels as a potential test for diagnosing hemochromatosis and related disorders

@article{Kaneko2010MeasurementOS,
  title={Measurement of serum hepcidin-25 levels as a potential test for diagnosing hemochromatosis and related disorders},
  author={Yoshibumi Kaneko and Hiroaki Miyajima and Alberto Piperno and Naohisa Tomosugi and Hisao Hayashi and Natsuko Morotomi and Ken-ichi Tsuchida and Takaaki Ikeda and Akihisa Ishikawa and Yusuke Ota and Shinya Wakusawa and Kentaro Yoshioka and Satoshi Kono and S. Pelucchi and Ai Hattori and Yasuaki Tatsumi and Toshihide Okada and Masakazu Yamagishi},
  journal={Journal of Gastroenterology},
  year={2010},
  volume={45},
  pages={1163-1171}
}
Iron overload syndromes include a wide spectrum of genetic and acquired conditions. Recent studies suggest suppressed hepcidin synthesis in the liver to be the molecular basis of hemochromatosis. However, a liver with acquired iron overload synthesizes an adequate amount of hepcidin. Thus, hepcidin could function as a biochemical marker for differential diagnosis of iron overload syndromes. We measured serum iron parameters and hepcidin-25 levels followed by sequencing HFE, HJV, HAMP, TFR2, and… CONTINUE READING
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Measurement of serum hepcidin-25 levels as a potential test for diagnosing hemochromatosis and related disorders

  • BA van Dijk, CM Laarakkers, SM Klaver, EM Jacobs, LJ van Tits, MC Janssen
  • Br J Haematol
  • 2008
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