Measurement of sealing resistance of cell-electrode interfaces in neuronal cultures using impedance spectroscopy

@article{Buitenweg1998MeasurementOS,
  title={Measurement of sealing resistance of cell-electrode interfaces in neuronal cultures using impedance spectroscopy},
  author={Dr. J. R. Buitenweg and Wim L. C. Rutten and W. P. A. Willems and J. W. van Nieuwkasteele},
  journal={Medical and Biological Engineering and Computing},
  year={1998},
  volume={36},
  pages={630-637}
}
Sealing resistance is highly significant with respect to the electrical neuronelectrode contact because it decreases the stimulation threshold of neurons cultured on a planar micro-electrode array. A method is proposed for measurement of the sealing resistance using impedance spectroscopy. The effect of the sealing resistance on the total impedance spectrum of a cell-electrode interface is modelled for complete coverage of the electrode by the cell. Sensitivity analysis demonstrates that the… CONTINUE READING
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