Measurement of salivary cortisol with liquid chromatography-tandem mass spectrometry in patients undergoing dynamic endocrine testing.

@article{Perogamvros2010MeasurementOS,
  title={Measurement of salivary cortisol with liquid chromatography-tandem mass spectrometry in patients undergoing dynamic endocrine testing.},
  author={Ilias Perogamvros and Laura J Owen and Brian G Keevil and Georg Brabant and Peter Trainer},
  journal={Clinical endocrinology},
  year={2010},
  volume={72 1},
  pages={17-21}
}
OBJECTIVE Liquid chromatography-tandem mass spectrometry (LC-MS/MS) eliminates cross-reactivity, which is a major limitation of immunoassays used for the measurement of salivary cortisol (SalC). We aimed to evaluate the potential of SalC measured by LC-MS/MS in patients undergoing assessment of the HPA axis. DESIGN AND PATIENTS Cross-sectional study of 78 patients admitted for routine testing in a specialized endocrine unit. MEASUREMENTS Matched serum and saliva samples were collected from… CONTINUE READING