Measurement of regional neuronal removal of norepinephrine in man.

  title={Measurement of regional neuronal removal of norepinephrine in man.},
  author={David S Goldstein and Reuven Zimlichman and Robin Stull and Joan Folio and Paul D. Levinson and Harry R. Keiser and Irwin J. Kopin},
  journal={The Journal of clinical investigation},
  volume={76 1},
We describe here and validate an in vivo technique to measure the regional proportionate removal of norepinephrine (NE) by neuronal uptake (Uptake1) in man. The measurement is based on the steady-state arterial and venous concentrations of tritiated NE and tritiated isoproterenol (ISO) during simultaneous infusion of both. The validity of this technique depends on the removal of circulating NE, but not of ISO, by sympathetic nerve endings and on there being no other factor contributing to the… CONTINUE READING