Measurement of radiotracer concentration in brain gray matter using positron emission tomography: MRI-based correction for partial volume effects.

@article{MllerGrtner1992MeasurementOR,
  title={Measurement of radiotracer concentration in brain gray matter using positron emission tomography: MRI-based correction for partial volume effects.},
  author={Hans Wilhelm M{\"u}ller-G{\"a}rtner and Jonathan M. Links and Jerry L. Prince and R. Nick Bryan and Elliot R. McVeigh and Jeffrey P. Leal and Christos Davatzikos and James Frost},
  journal={Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism},
  year={1992},
  volume={12 4},
  pages={571-83}
}
Accuracy in in vivo quantitation of brain function with positron emission tomography (PET) has often been limited by partial volume effects. This limitation becomes prominent in studies of aging and degenerative brain diseases where partial volume effects vary with different degrees of atrophy. The present study describes how the actual gray matter (GM) tracer concentration can be estimated using an algorithm that relates the regional fraction of GM to partial volume effects. The regional… CONTINUE READING
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