Measurement of partial agonist activity of pindolol.

  title={Measurement of partial agonist activity of pindolol.},
  author={S. George Carruthers and Y Twum-Barima},
  journal={Clinical pharmacology and therapeutics},
  volume={30 5},
The partial agonist activity of pindolol was assessed by examining the action of cumulative doses on the heart rate of resting, standing, and exercising healthy men and by studying the interaction of pindolol with metoprolol, a beta blocker devoid of partial agonist activity. Pindolol did not affect resting or standing heart rates (RHR, SHR) but reduced the heart rate after vigorous exercise by approximately 25%. The flatter dose-response curve of pindolol for exercise heart rate (EHR) has been… CONTINUE READING